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Cordeiro S, Silva B, Martins AM, Ribeiro HM, Gonalves L, Marto J

3.1.5 HIF-1 and HIF-2 HIF-1 and 2 are TFs, playing a significant role in proliferation, oxidative stress, inflammation, and apoptosis, by binding to its hypoxia response elements (HRE) on the promoter region of its target genes under hypoxic or toxic conditions ( 3.1.6 NF-B NF-B, a master regulator of genes involved in cytokine production and cell survival, plays an important role in Mn-induced neurotoxicity (for review, see Pajarillo et al., 2021)

In a staphylococcal infection setting, riboflavin has demonstrated its anti-inflammatory property through reductions in NF-B, COX2 (cyclooxygenase 2), TNF-, NO, IL-1 (interleukin 1 beta) reducing iNOS (inducible NO synthase) synthesis, as well as an elevation in anti-inflammatory cytokine IL-10 (interleukin 10), and modulation of MCP-1 (monocyte chemoattractant protein 1) function, a potent chemoattractant ( On the other hand, riboflavin has an indirect anti-inflammatory activity through vitamin D metabolism

10.1101/gad.276428.115 22 ChengH.YangZ

10.1016/s0161-6420(95)31034-2 Ophthalmology 135 WangH.HanX.WittchenE