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Oral administration introduces too many variables: fed vs fasted state, gut transit time, individual differences in hepatic enzyme expression, co-administration of CYP3A4 inhibitors or inducers

Unlike peptides, which consist of chains of amino acids joined by peptide bonds, 5-Amino-1MQ is built around a quinolinium ring system an aromatic heterocyclic structure commonly encountered in medicinal chemistry

In severe cases, it may lead to Wernicke-Korsakoff syndrome, causing severe confusion and coordination problems