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doi: 10.1016/j.phymed.2010.02.002 190

Astrocyte state transitions: balancing protection and pathology Traditionally, neuronal plasticity has been regarded as the principal mechanism underlying adaptive responses in the CNS, encompassing synaptic remodeling and circuit reorganization that support learning and memory

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Drug Disc Today

Interestingly, the phosphodiesterase inhibitor Cilostazol (used in peripheral vascular disease treatment) is able to improve cognitive function in mice by increasing the hippocampal production of IGF-I through stimulation of sensory neurons [350]