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Among them, DNL201, a CNS-penetrant LRRK2 inhibitor, has been shown in preclinical studies to effectively reduce LRRK2 activity and restore lysosomal function

The activation of NRF2 by this mechanism enhances the transcription of genes involved in antioxidant defense and cystine/glutamate exchange, particularly those coding for components of the xCT antiporter (such as SLC7A11), which imports cystine in exchange for glutamate

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