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doi: 10.1002/jnr.22338 141

Kellum, J.A., McCullough, P.A., Mehta, R.L., Murray, P.T., Ronco, C., Eds

In: Oxidative Stress: Eustress and Distress

Collectively, these immunohistochemical results provide strong evidence that LCR confers significant hepatoprotection against methotrexate-induced liver injury through modulation of inflammatory pathways, reduction of oxidative stress, and regulation of glucose transporter expression

Although urocortin 1 can also activate CRH-R1, urocortin 1 knockout mice appear to have normal HPA axis function, suggesting that urocortin 1 does not have a significant regulatory role on the axis (61)