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Signs include taking more than prescribed, running out early, doctor shopping, using the medication for emotional rather than physical pain, inability to stop despite wanting to, and continued use despite significant negative consequences

Individuals should consult a qualified healthcare professional, use products from reputable sources, and understand that current evidence is limited

Immunogenicity, often triggered by double-stranded RNA contaminants or incomplete purification, adds another layer of complexity

Chromatography was conducted with UV detection (215 nm) at 50C using a 1-8 pl injection volume and a flow rate of 0.3 ml/min