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doi: 10.1007/s12013-024-01484-6

for example, donepezil has been reported to interact with both P -gp and BCRP, underscoring how BBB efflux biology may influence brain drug availability and therapeutic response ( In AD, BBB integrity is often altered due to vascular dysfunction, inflammation, and cerebral amyloid angiopathy (Sweeney et al., 2018

Optimization of dosing and administration: Research is being conducted to determine the optimal dosing and administration protocols for BPC-157 to maximize its therapeutic effects while minimizing potential side effects.

HA is a polysaccharide that is produced naturally in the extracellular matrix and constitutes the major part of it, with which it contributes significantly to barrier repair and wound healing [22, 23]

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