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It binds to incretin receptors in the hypothalamus and gastrointestinal tract, reducing appetite signaling while simultaneously slowing gastric emptying

However, treatment with ketogenic Harlan Teklad TD 96355 diet containing 90.5% fat, 0.3% carbohydrate, and 9.2% protein reduced hippocampal TNF- and PPAR activation and down regulate the expression of hippocampal COX-2

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The exposure of colorectal cancer cell lines to sublethal doses of paclitaxel fostered an epithelial-to-mesenchymal transition, which was antagonized by all-trans retinoic acid (ATRA) co-treatment

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