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The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Tylenol's Impact on Glutathione and Liver Damage PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC Acetaminophen Toxicity: OPPOSITE EFFECTS OF TWO FORMS OF GLUTATHIONE PEROXIDASE ScienceDirect

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