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SIRT1 is part of a family of proteins called sirtuins, known as longevity genes. It uses NAD+ as a fuel source to repair DNA, reduce inflammation, and improve stress resistance

Previous studies have shown that inhibiting SIRT2 may enhance the stability of glucokinase (GCK) regulatory proteins, accelerate aldolase A degradation, and inhibit -cell insulin secretion via modulation of the Akt/glycogen synthase kinase-3 (GSK3)/-catenin pathway, collectively reducing glycolytic flux (42)

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Clinically, patients with hypothyroidism and advanced hepatic fibrosis exhibit elevated liver stiffness values on elastography, which are strongly associated with increased HCC risk (97)