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However, chronic excessive alcohol consumption leads to significant metabolic disruptions: (1) Disruption of the NADH/NAD + Ratio: This imbalance enhances respiratory chain activity, increases oxygen consumption, and promotes ROS formation (Yang et al., 2022)
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2.3.2 Dysfunction of innate immune cells in MS Innate immune cells within the CNS are key drivers and modulators of damage in MS
Cell-type-specific gene programs suggest immune and stromal drivers of relapse in colorectal cancer
