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Of note, data on the role of circadian machinery in anti-tumor immunity suggest a possible role of circadian machinery in the development of cold tumors through the accumulation of immune-suppressive cells in the microenvironment and through the regulation of the expression of PDL1 and CTLA4, two major targets of the current immunotherapy 126

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Preclinical studies employing a wide range of materialsfrom natural polysaccharides to synthetic amphiphilic polymershave consistently demonstrated their practicality as SIMs, underscoring their ability to enhance procedural efficiency while functioning as multifunctional drug delivery platforms

ONS-5010 is an ophthalmic formulation of bevacizumab, a VEGF inhibitor sold by Roches Genentech as Avastin for several types of cancer

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