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Shi SY, Lu SY, Sivasubramaniyam T, Revelo XS, Cai EP, Luk CT, Schroer SA, Patel P, Kim RH, Bombardier E, Quadrilatero J, Tupling AR, Mak TW, Winer DA, Woo M (2015) DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice

When medical ozone contacts blood components, it creates controlled oxidative exposure that paradoxically reduces chronic oxidative stress over time by upregulating endogenous antioxidant systems: glutathione, superoxide dismutase, and catalase production increases in response

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Prolonged metabolic stress and redox imbalance alter substrate preference, hinder pyruvate dehydrogenase activity, and decrease the efficacy of oxidative phosphorylation, ultimately resulting in energetic insufficiency (3, 41)

[PubMed ID: 9230243]