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Glycogen breakdown is vital to produce NADPH

After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity) and reaching pre-arrival body weights (38 g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation

doi: 10.1002/(sici)1097-4547(19990101)55:1 3.0.co;2-j 201 KarperienAAhammerHJelinekHF

Furthermore, with age, the efficiency of the DNA Damage Response in eukaryotes, which is responsible for preventing the replication of damaged DNA, also declines (Zhu et al., 2024)