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Tendon and Ligament Repair Moderate to Strong Evidence Evidence Rating: Moderate-Strong (Several animal studies, some independent replication) Research support for musculoskeletal healing is substantial: Achilles tendon injuries Ligament damage (MCL, ACL) Rotator cuff healing General tendinopathy Surgical repair enhancement The FAK-paxillin mechanism and VEGF upregulation provide clear biological rationale for these effects

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Artificial extracellular matrices composed of collagen I and sulfated hyaluronan with adsorbed transforming growth factor 1 promote collagen synthesis of human mesenchymal stromal cells

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Mottaghi et al