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Neurological Manifestations: Higher Dose Requirements Vitamin B12 is key for our nerves and brain

Fan W, Bu W, Zhang Z, Shen B, Zhang H, He Q, Ni D, Cui Z, Zhao K, Bu J

Nilles M, Boedeker RH, Schill WB

4a, although the fluorescent ApoE-PDHD accumulated quickly alongside the wall of brain microvessels due to the binding function of ApoE, the fluorescence outside the cerebral vessels of mice injected with ApoE-free BEAGA-PDHD or ApoE-PDHD was hardly detected throughout the whole experiment time, suggesting that the ApoE decoration alone facilitated a low BBB-crossing efficiency 33

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