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doi: 10.1001/jamaoncol.2017.2411 76 AntoniaSJVillegasADanielDVicenteDMurakamiSHuiRet al

Hepatic (liver-related) causes The liver is a major reservoir for cobalamin, so liver disease is one of the more common explanations for a high B12

Vitamin B12 and Metformin The diabetes medicine, metformin, interferes with B12 absorption in the intestine by impeding the calcium-dependent intake mechanism