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TAMs and Tregs in the tumor microenvironment depend on FAO for energy, accumulation of fatty acids in this microenvironment promotes their survival and drives pro-tumor effects (330)

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Although these results suggest a mTORC1-dependent process such as 4EBP phosphorylation and subsequent CAP-dependent translation initiation is involved in the synthesis of a new protein(s), at this point we cannot definitively rule out a role for mTORC2 in threonine deprivationassociated cell death because our results thus far are based on the use of chemical inhibitors and global manipulation of AA balance

*Correspondence: Ying Huang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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