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In the tumor microenvironment, CLL cells are stimulated by various signals, including the activation of CD40 signaling, which enhances OXPHOS and glycolysis, increases the expression of antiapoptotic proteins, and is associated with venetoclax resistance

Therefore, we FACS-sorted splenic B cells from Gclc fl/fl mice (gated as in Supplementary Fig

Results MTX impact on cellular metabolism Initially, cells were treated with increasing doses of MTX for 48 or 96 hours to determine their IC50

Chittezhath M, Deep G, Singh RP, et al

Ethnobotanical study of medicinal plants used against human diseases in Zuway Dugda district, Ethiopia