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This involved 100 L of serum treated with 50 L of Ellmans reagent (19.8 mg of 5,5dithiobisnitrobenzoic acid in 100 mL of 0.1% sodium citrate) and 300 L of phosphate buffer (pH 8.0)

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In an in vivo study using a humanized mouse model of SLE, it was observed that CD19 CAR-Tregs delayed the onset of B cell lymphopenia, produced immunomodulatory cytokines, showed no toxicity or reprogramming towards Th17 pro-inflammatory cells, and furthermore, in the inflamed organs, restored the normal composition of the local immune site (76)

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Drugs currently being tested that target AATs are shown in (Table 1)