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Wu, X., Daniels, G., Lee, P

PDH activity was assessed from 1 mM [1- 14 C] pyruvate in the presence or absence of 5mM L-carnitine and the 14 CO 2 released was quantified by scintillation counting

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In a series of experiments on humans and mice, the researchers found that L-carnitine is broken down by gut bacteria to produce trimethylamine-N-oxide (TMAO), which previous research has linked to heart and artery damage

Using a mouse carotid artery injury (FeCl3) model, they found that exposure to a physiological dose of TMAO (100 mol) accelerated the formation of arterial thrombosis and shortened the duration of vascular occlusion (15), possibly due to the occurrence of acute coronary syndrome