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The skin starts to break down and sag more, causing fat to become more noticeable as it droops below the natural jawline

DOI: 10.1371/journal.pone.0136541

Animals were randomized and treated at palpable tumor size (0.08 to 0.2 cm) with the respective drugs: bevacizumab (10 mg/kg intraperitoneally, 3 per week for 2 weeks