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FIGURE 2 3.2 Inflammatory pathway activation via mtROS and mtDNA leakage 3.2.1 mtROS and the NLRP3 inflammasome mtROS is a potent activator of the NLRP3 inflammasome, a multiprotein platform composed of NLRP3, ASC, and caspase-1 (Wang et al., 2024)

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This regimen has been shown to be effective at causing airway enlargement in rodents after at least 6 full months of CS exposure [20, 21]

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