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As a result, cysteinyldopa synthesis is induced, leading to increased production of pheomelanin, which is yellow-red

501,502 Clinical trials demonstrated a clinical remission rate of 18.7% at 8 weeks and 27.6% at 24 weeks in patients treated with ustekinumab, with an adverse event rate of 2.3%

Hydrogen sulfide (H 2 S) is a third gaseous bioactive substance produced in different mammalian cells, both exogenous and endogenous H 2 S have been reported to cause vascular smooth muscle relaxation and decrease in blood pressure [6], thus a physiological vasodilator [7]