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PDI is a ubiquitous dithiol/disulfide oxidoreductase of the thioredoxin superfamily in mammalian cells, and catalyzes the formation of intra- and inter-molecular disulfide bridges in proteins [13,14,15,16]

Meanwhile, in the functional tests, we observed that the tubular formation ability of endothelial cells was significantly decreased after OGD treatment (Figure 3E)