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To determine changes in mitochondria of LECs, HLEB3 cells and C57BL/6 J mice were pretreated with CeNPs, followed by UVB radiation (60 mJ/cm 2 for HLEB3 cells, 3.6 kJ/m 2 for mice), and corresponding samples were collected

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As a result, oxidative stress invariably leads to cell death

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Future directions First, define exposureresponse with quantitative pharmacokinetics and, where possible, receptor-occupancy or target-engagement biomarkers to guide dose selection across tissues