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Shelise Edwards, MD, FACEP, is a board-certified emergency medicine physician

The algorithms identified numerous metabolites from leukotriene metabolism, arachidonic acid metabolism, and chondroitin/heparan sulphate biosynthesis and degradation as significant for the M1 phase, while the major metabolites for the M2 phase were from glycolysis, OXPHOS and TCA cycle

It is noteworthy that the lipid peroxidation and metabolic disorders of intracellular LOOHs are mainly related to iron metabolism (Figure 1B), glutathione (GSH)-dependent pathway (Figure 1C), and coenzyme Q 10 (CoQ 10 )-dependent pathway (Figure 1D)