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The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway and involves selective degradation of their C-terminal region containing ankyrin repeats

In Rac1 conditional KO mice where Rac1 was deleted in mature neurons, working memory in the delayed matching-to-place (DMP) water maze test was impaired (Haditsch et al., 2009), implicating Rac1 in memory acquisition but not in memory consolidation

HFD and Met and choline-deficient diet (MCD) can mimic human diseases histological and metabolic abnormalities and are commonly used to establish NAFLD mouse models

This helps raise the baseline energy threshold, potentially reducing the severity and duration of crashes following physical or cognitive exertion

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