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Tofogliflozin can increase expression of the -oxidation genes ACOX1 and CPT1 by upregulating PPAR, thereby reducing renal lipid deposition [50]

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The aim of the study was to evaluate the effect the dual action on GPBAR1 and RORt, by the administration of Allo-LCA, in preventing the development of NASH inflammation and fibrosis

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Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]