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Therefore, ( i ) osteophytes present within the vertebral column of osteoporotic patients and locally counteract the general bone loss with osteoporosis, ( ii ) osteophytes also form within rheumatoid arthritic joint structures supported by or persisting the high inflammatory load, ( iii ) osteophytes are located within pathologically degenerated joints of osteoarthritic patients whereby joint instability or mechanical joint damage are present, and iv) osteophytes can be found in joints of healthy people 6,7,8