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Homocysteine comes from amino acid cysteine and methionine

Moreover, prolonged inflammation leads to the accumulation of ROS in the wound and limits the antioxidant capacity of cells to clear excess ROS (Wagener et al., 2013)

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Hypoxia increases expression of selected blood-brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers