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Increased activity of these phase II detoxification enzymes enhances the bodys ability to manage oxidative stress and inflammatory mediators that contribute to metabolic syndrome (Ngo and Duennwald, 2022)

A synergistic interaction is defined as a combination of stressors that results in a greater effect than the cumulative expected effect from independent exposure 34

Cis-aconityl group Cis -aconityl group, an amide derivative of maleic acid, has also been employed as an acid-cleavable linkage for designing pH-responsive polymer-drug conjugates and drug carriers