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The importance of normal IGF-I production in humans was confirmed by the pre-natal growth failure reported in patients with IGF1 mutations (Jin et al., 2008)

Animal models in thyroid nodules usually arise from induced genetic mutations or an exposure to substances that may trigger abnormal growth of thyroid cells (Morr et al

All authors thoroughly reviewed and agreed upon the final manuscript

It appears to interact with key biological systems, such as the nitric oxide pathway and antioxidant defenses, which may explain its broad therapeutic effects