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10.21037/atm-21-4080 100 LiD

Each mouse commenced the experiment in one arm, designated the home arm, and was allowed to explore for 10 min

If PIM1 regulates NRF2, and persister cancer cells are dependent on glutathione 4 peroxidase (GPX4) and methionine extra-supply (transsulfuration pathway), then PIM1 inhibition might serve as a relevant therapeutic strategy

Approaches such as intranasal nose-to-brain delivery, receptor-mediated BBB transport, focused ultrasound-based BBB opening, and implantable hydrogel systems are being actively explored to improve access to brain tissue