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However, for neuroprotective agents to be successful, it is essential that the penumbra region that surrounds the core infarct which has reduced cerebral blood flow (10-35%), but has energy reserves and synaptic activity is redeemable 96

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At 0.5mm, a stamped microneedle traverses the stratum corneum (typically 10 to 30 microns), passes through the viable epidermis (50 to 100 microns), and lands in the upper papillary dermis (which begins around 100 to 150 microns deep)

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DOI: 10.1007/s12640-018-9987-y

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