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During ischemia, NF- is produced and translocated to the nucleus where it stimulates the production of pro-inflammatory cytokines ( The preferred treatment approaches for ischemic stroke include rapid vascular recanalization and the use of recombinant tissue plasminogen activator (tPA) whenever possible ( Most mammals, including humans, produce melatonin, which functions as an amine hormone and scavenger of free radicals

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doi: 10.3390/plants12040935 51 Garcia-MasJ.BenjakA.SanseverinoW.BourgeoisM.MirG.GonzlezV

Changes to blood brain barrier integrity and function are also suggested to result from elevated blood levels of Hcy [86]

Research indicates that certain probiotic strains can enhance resilience and promote the re-establishment of gut microbial equilibrium following disturbances such as antibiotic therapy or other physiological stressors, even though a precise, universally accepted definition of a healthy microbiome remains an ongoing scientific challenge (28)