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Then, until 1980, eight more drugs were approved by the USFDA for the treatment of epilepsy

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Abbreviations AchE: Acetylcholinestrase AD: Alzheimers disease A: Amyloid-beta Bax: Bcl-2-associated X protein DON: Donepezil ELT: Escape latency time GSH: Reduced glutathione LDH: Lactate dehydrogenase MAP: Myelin associated proteins MBP: Myelin basic protein MD: Malondialdehyde MEM: Memantine NEFL: Neurofilament light chain NMDA: N-Methyl-d aspartate No: Nitric oxide SOD: Superoxide dismutase SSZ: 6-chloro-N-cyclohexyl-4-(1Hpyrollo[2,3-b] pyridin-3-yl] pyridin-2-amine TSTQ: Time spent in the target quadrant LA: Locomotor activity MWM: Morris water maze BCT: Beam-crossing task References Gustavsson A, Norton N, Fast T, Frlich L, Georges J, Holzapfel D, Kirabali T, Krolak-Salmon P et al (2023) Global estimates on the number of persons across the Alzheimers disease continuum

A linear gradient of mobile phases was employed, where solvent A comprised 0.1% (v/v) formic acid (##1209246, Sigma Aldrich, Germany) and solvent B consisted of 80% (v/v) acetonitrile (##741857, Sigma Aldrich, USA) with 0.1% (v/v) formic acid

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