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While direct experimental evidence comparing the responsiveness of specific -cell subpopulations to SCFAs, GLP-1, or other microbiota-derived metabolites remains limited, existing resources such as HPAP (Kaestner et al., 2019), reveal clear associations between -cell maturity, chromatin accessibility, metabolic state, and the capacity to sense exogenous signals

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Acetaldehyde was found to be metabolized by the tubules at high rates and in a dose-dependent manner in all four species

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