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Early case series and open-label studies support feasibility and biological plausibility, whereas randomized trials show mixed clinical signals, highlighting donor-dependent effects, protocol heterogeneity (preconditioning, route, dose/frequency), and the need for engraftment-aware endpoints [252,253,254,255]

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Munzel et al., 1995b

This upregulates Phosphatase and Tensin Homolog (PTEN) and inhibits the phosphorylation of AKT

All solutions were filtered through 0.45-m nylon filter discs (Millipore, Billerica, MA, USA) prior to HPLC analysis