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Post-translational modification and mitochondrial function in Parkinsons disease

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Mechanism of Action of IGF-1 LR3 IGF-1 LR3 binds to the IGF-1 receptor (IGF1R) , activating intracellular pathways such as: PI3K/Akt/mTOR pathway Drives protein synthesis and muscle growth MAPK pathway Influences cell proliferation and differentiation Key effects include: Stimulating muscle stem cells (satellite cells) Increasing nitrogen retention in muscle tissue Enhancing glucose uptake for energy and glycogen replenishment Promoting connective tissue healing 6

There are significant disparities in clinical trial enrollment in the U.S

doi: 10.1038/s41577-024-01104-7 137 HenkelJ