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The pathological hallmark of HD is iron accumulation and abnormal levels of glutamate and glutathione (Skouta et al., 2014

They also identified a variety of studies that were positive or suggestive of sub-clinical nephrotoxic effects, occurring in the same general dose range associated with sub-clinical CNS effects

The effect of Liver Explore HIFs on progression to LRE (e.g., decompensation, liver transplantation) in ASH patients was assessed using Cox proportional hazards regression