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Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity

NAC heavily regulates Phase II (Conjugation), the essential follow-up process where these dangerous intermediate metabolites are bound to other molecules to make them water-soluble and safe for excretion via urine or bile

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MiallotRMilletVRogerAFenouilRTardivelCMartinJ-Cet al

Functional enrichment analysis indicated these intersecting genes are primarily involved in biological processes including oxidative stress responses, smooth muscle cell proliferation, and reactive oxygen species (ROS) responses, closely matching RA pathological features such as excessive inflammatory factor release and oxidative stress injury ( We further applied three classical machine learning algorithms (LASSO, RFE-RF, and SVM) to cross-validate and identify two core genes, GPX3 and MYC, which were subsequently validated using an MLP model