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GH and IGF-1 are related but not identical: GH has stronger direct effects on fat metabolism, while IGF-1 is more directly linked to tissue growth and repair signaling

Symptoms frequently begin or worsen during periods of significant hormonal changes, predominantly at puberty (15.767.3%), but also during pregnancy/lactation (9.563.1%), menopause (1.921%), or with the use of exogenous hormones like oral contraceptives (1.23.8%) 16

However, high doses (a single intraperitoneal injection of 250 mg/kg) of FA can also cause AKI in mice, and continuous injection can cause AKI to convert to chronic kidney disease (CKD) in mice 347

High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma

20241112), State Key Laboratory of Traditional Chinese Medicine Syndrome (QZ2023ZZ11), Chinese Medicine Guangdong Laboratory (HQL2024PZ005), the 2025 Annual Basic and Applied Fundamental Research Topics-Young Doctor Launch Program (2025A04J4194), and Postdoctoral Research Project of the Second Affiliated Hospital of Guangzhou University of Chinese Medicine (No