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Although the food and drug administration (FDA) has classified curcumin as generally recognized as safe (GRAS) and generally well-tolerated, high doses can lead to issues such as hepatotoxicity, gastrointestinal disturbances (including nausea, diarrhea, or stomach pain), and tolerance problems that may be difficult to manage [12, 13]

And unlike direct antioxidant supplements (e.g., vitamin C or E), which often fail in clinical trials due to poor bioavailability or paradoxical pro-oxidant effects, Epitalon works endogenously, stimulating the body's systems with surgical precision

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10.1016/j.peptides.2014.02.015 4 AllenJ

Because retatrutide affects several pathways in the body, its dosing requires careful management