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It's common for arm pain after a vaccine to be more intense at night

While we understand the comment that MRFs may not be primarily intended for direct patient use, we disagree that they have little utility for patients and the public

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SAEs relatedness to the administration of vitamin B 12 or placebo will be judged by the investigator/designee, the Ethics Committee and the DSMB who will have access to all relevant investigations, clinical assessments and if require unblinding allocated interventions