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The concerted action of a positive charge and hydrogen bonds dynamically regulates the pKa of the nucleophilic cysteine in the NrdH-redoxin family

(2017) noted that patients with hepatic steatosis have depleted NAD+ and glutathione as a primary feature of the condition

Siddiqui, Virginia Commonwealth University, Michael Silver, Labcorp, Margery Connelly, University of Florida and Arun Sanyal, Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, Richmond, VA Background: Liver plays a central role in lipoprotein metabolism and is a key driver of atherogenesis

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Collectively, these results indicate that oxidative stress is a powerful driving force behind antiretroviral-induced toxicity and has important roles in premature-and-accelerated-aging symptoms (Blas-Garcia et al., 2011)