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The detection of L-glutathione and total phenolic compounds further supports the antioxidant capacity of APE

Notably, the side chain of W276 6.48 rotates nearly 180 and tilts ~3 toward the extracellular end, and together with the side chain of F279 6.51 , it also displays upward movement, therefore pushing out the extracellular end of TM6 and enlarging the ligand-binding pocket, subsequently impeding the formation of a salt bridge by dragging R283 6.55 away from E124 3.33 (Fig

Mishra SK, Kumar BS, Khushu S, Singh AK, Gangenahalli G (2017) Early monitoring and quantitative evaluation of macrophage infiltration after experimental traumatic brain injury: a magnetic resonance imaging and flow cytometric analysis

In the contemporary context, vitamin C is best known as a potent antioxidant

By redirecting electron flux and preventing excessive reduction of the respiratory chain, AOX mitigates ROS overproduction while maintaining redox balance and metabolic continuity particularly under drought, salinity, or temperature extremes