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The drug reduces hepatic glucose production, enhances glucose uptake in the peripheral tissues and increases insulin sensitivity 115

However, inhibition of ferroptosis and RhoA effectively mitigated these alterations, suggesting that RhoA and ferroptosis inhibition may modulate blood lipid metabolism in DMM mice (Fig

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In addition, VRK2 overexpression confers PC cells resistant to ferroptosis induced by exogenous ROS through promoting ER-to-Golgi trafficking of SLC7A11, which echoes the findings that PC cells with high expression of VRK2 have an elevated basal level of GSH