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Finely-tuned calcium oscillations in osteoclast differentiation and bone resorption

While this may be true for the terminal phase of WD in which massive copper overload causes liver failure, an increasing body of evidence demonstrates that such uncontrolled Fenton chemistry reactions do not drive disease pathogenesis

Kudoh Y, Aoyama S, Torii T, Chen Q, Nagahara D, Sakata H, et al

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Conversely, -syn dysregulates iron homeostasis: it exhibits ferrireductase activity, reducing Fe 3+ to Fe 2+ and elevating labile iron levels, while its overexpression redistributes iron to perinuclear inclusions