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Wang R, Zhao Y, Zhou L, Lin F, Wan M, Gan A, et al

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This subsequently activates CaMKII and NADPH oxidase on the cell membrane, which then triggers the release of cytochrome C from the mitochondria, promoting the generation of ROS and apoptotic bodies, thereby initiating caspase-9 mediated apoptosis (Munoz-Pinedo et al., 2006

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